KMID : 0356619920070040397
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Journal of Korean Society of Endocrinology 1992 Volume.7 No. 4 p.397 ~ p.401
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ase of Isolated ACTH Deficiecy
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Abstract
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Isolated ACTH deficiency is a rare cause of secondary adrenocortical insufficiency caused by the defect of synthesis or release of ACTH and is characterized by hypoglycemia, weight loss and hypotension.
A 40-yr-old female developed fever and mental confusion soon after flu-like illness. She was found to have severe hypoglycemia (blood glucose=29 mg/dl), negligible plasma cortisol and ACTH levels. The serum cortisol was unresponsive to rapid ACTH
stimulation and insulin-induced hypoglycemia but other pituitary function was intact. Brain MRI failed to reveal any anatomic abnormalities of the sellar or suprasellar area consistent with the defect of pituitary ACTH secretion. No discernible
thyroid
autoantibody was recognized.
The case was conclude to be isolated ACTH deficiency without other endocrine or autoimmune disorder. (J Kor Soc Endocrinol 7 : 397 ~ 401, 1992)
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KEYWORD
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